Immunoprofiling of Cancer-Specific Antibodies on Protein Microarrays of Novel Tumor Antigens

Michael Tainsky, Professor, Wayne State University

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Launch presentation

About the speaker

Dr. Michael A. Tainsky, Ph.D., is Director of Molecular Biology and Genetics at Karmanos Cancer Institute, and Professor of Pathology at Wayne State University School of Medicine. He received his undergraduate degree in Chemistry with honors from New York University in 1971 and his doctorate in Molecular and Cellular Biology from Cornell University in 1977. He came to the Detroit area in 1998 from the M.D. Anderson Cancer Center in Houston, Texas. Dr. Tainsky has a particular interest in inherited cancer syndromes and the development of blood tests for the early detection of cancer using protein microarrays. Dr. Tainsky holds the Barbara and Fred Erb Endowed Chair in Cancer Genetics.

Abstract

The humoral immune response is an exquisite biosensor of novel proteins expressed by tumor cells. Panels of tumor antigens could provide a sensitive and specific multianalyte immunoassay for the presymptomatic of cancer. Using a high-throughput antigen cloning method, a panel of epitopes/antigens have been isolated that react with autoantibodies to tumor proteins in the serum of patients with cancer. The binding properties of these serum antitumor antibodies on microarrays and advanced bioinformatics tools led to a panel of diagnostic antigens. There are numerous advantages of employing serum antibodies as the analytes, not the least of which is the ability to readily adapt these assays to standard clinical platforms and their application to personalised immunotherapy. Early detection using panels of tumor antigens will lead to individualised interventions based on each specific immunoprofile.

Launch presentation